EGFR-IN-140
Product Specifications
Target
EGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling
Bioactivity
EGFR-IN-140 (Compound 31) is an inhibitor of EGFR, effectively targeting both wild-type EGFR and the EGFRL858R/T790M/C797S mutant, with Ki values of 0.95 nM and 2.1 nM, respectively. Additionally, it inhibits EGFRdel19/T790M/C797S in Ba/F3 cells with an IC50 of 56.9 nM and demonstrates antitumor activity in mouse models.
Smiles
CCC1=CN2C(=CC(=N2)NC3=NC(=NC=C3)N4CC[C@H]([C@H](C4)F)OC)N1C5CCC6(CC5)CCN(C6=O)C
Molecular Formula
C27H37FN8O2
Molecular Weight
524.633
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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