PFM046
Product Specifications
CAS Number
3053859-57-4
Target
Stearoyl-CoA Desaturase (SCD) |||Fatty Acid Synthase|||Liver X Receptor
Related Pathways
Metabolism
Bioactivity
PFM046 is an antagonist of the liver X receptor (LXR), effectively inhibiting the activation of LXR? and LXR?, with IC50 values of 2.04 ?M and 1.58 ?M respectively. It reduces the expression of SCD1 and FASN while increasing ABCA1 expression, and demonstrates antitumor activity in mouse models.
Smiles
C[C@@]12[C@]([C@]3([C@](CC1)([C@]4(C)C(=CC3)C[C@@H](O)CC4)[H])[H])(CC[C@@]2([C@@H]([C@H](CC5=CC=CC=C5)O)C)[H])[H]
Molecular Formula
C29H42O2
Molecular Weight
422.643
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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