NPC26
Product Specifications
CAS Number
864860-32-2
Target
Reactive Oxygen Species, AMPK
Related Pathways
PI3K/Akt/mTOR signaling, Chromatin/Epigenetic, Immunology/Inflammation, Metabolism, NF-κB
Bioactivity
NPC26 is a small molecule that disrupts mitochondrial function and exhibits antitumor activity. It shows significant antiproliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29) . NPC26 induces mitochondrial permeability transition pore (mPTP) opening, generates reactive oxygen species (ROS), and triggers cell death. Additionally, NPC26 kills CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway.
Smiles
O=C(OCC)C1=C(SC2=C1CC(NC2(C)C)(C)C)NC(=O)C=3SC(=CC3)N(=O)=O
Molecular Formula
C19H23N3O5S2
Molecular Weight
437.533
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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