NF-κB/MAPK-IN-2
Product Specifications
Target
NF-κB, p38 MAPK
Related Pathways
NF-κB, MAPK
Bioactivity
NF-κB/MAPK-IN-2 (compound 14) is a potent inhibitor of NF-κB and MAPK pathways. It effectively reduces the protein expression levels of p-p65, p-IκB, p-p38, p-JNK, and p-ERK. This compound decreases the release of TNF-α and IL-6 induced by LPS and inhibits the nuclear translocation of p65 and c-Fos. NF-κB/MAPK-IN-2 shows potential for research in sepsis.
Smiles
CCOC(=O)C1=NOC2=C1C[C@]3([C@H]([C@]2(C)COC(=O)CCC(=O)N4CCOCC4)CC[C@@]5([C@@H]3CC=C6[C@]5(CC[C@@]7([C@H]6CC(CC7)(C)C)C(=O)OCC8=CC=CC=C8)C)C)C
Molecular Formula
C49H66N2O9
Molecular Weight
827.056
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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