JB300
Product Specifications
CAS Number
3038446-90-8
Target
PROTACs, Aurora Kinase
Related Pathways
Chromatin/Epigenetic, Cell Cycle/Checkpoint, PROTAC
Bioactivity
JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.
Smiles
C([C@@]1(C(NCCOCCOCCNC(COC2=C3C(C(=O)N(C3=O)C4C(=O)NC(=O)CC4)=CC=C2)=O)=O)CC[C@@H](OC5=C(F)C(Cl)=CC=C5)CC1)C=6N=C(NC7=NC=CS7)C=CC6
Molecular Formula
C43H45ClFN7O10S
Molecular Weight
906.375
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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