3-AP-Me
Product Specifications
CAS Number
1184391-57-8
Target
PERK, Apoptosis, p38 MAPK, JNK
Related Pathways
MAPK, Apoptosis
Bioactivity
3-AP-Me is the dimethyl derivative of the ribonucleotide reductase inhibitor 3-AP (SML0568) . It activates the endoplasmic reticulum (ER) stress pathway by promoting eIF2α phosphorylation and upregulating gene expression of transcription factors ATF4 and ATF6, thereby inducing apoptosis. Additionally, 3-AP-Me activates cellular stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase, leading to the upregulation of spliced mRNA variant XBP1. It is applicable in cancer research.
Smiles
S=C(NN=CC1=NC=CC=C1N)N(C)C
Molecular Formula
C9H13N5S
Molecular Weight
223.298
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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