Tubulin polymerization-IN-73
Product Specifications
Target
Apoptosis, Microtubule Associated
Related Pathways
Apoptosis, Cytoskeletal Signaling
Bioactivity
Tubulin polymerization-IN-73 (Compound 37) is an inhibitor of microtubule polymerization with an IC50 of 1.8 μM. It induces cell cycle arrest at the G2/M phase and triggers apoptosis in A549 cells. The compound inhibits the proliferation of both A549 WT and A549/T resistant cells with IC50 values of 0.023 μM and 0.057 μM, respectively. Additionally, Tubulin polymerization-IN-73 demonstrates antitumor activity in mouse models.
Smiles
COC1=C(C=C(C=C1)C2=CC(=C3C(=C2)NC=N3)C4=C(C(=C(C=C4)OC)OC)OC)N
Molecular Formula
C23H23N3O4
Molecular Weight
405.446
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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