PIN1 degrader-1
Product Specifications
Target
Others
Related Pathways
Others
Bioactivity
PIN1degrader-1 (Compound 158H9) is an inhibitor of the peptidyl-prolyl cis-trans isomerase (Pin1), with an IC50 of 21.5 nM. It covalently binds to Cys113 on Pin1, inducing conformational changes that decrease the protein's stability and lead to proteasome-dependent degradation. PIN1degrader-1 also inhibits the viability of various cancer cells, making it useful for cancer research.
Smiles
C1CCN([C@@H](C1)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N)C(=O)[C@H](CC4=CNC5=C4C=CC(=C5)Cl)NC(=O)CCl
Molecular Formula
C30H32Cl2N6O4
Molecular Weight
611.519
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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