NA-17
Product Specifications
CAS Number
1708948-28-0
Target
MDM-2/p53, Apoptosis
Related Pathways
Apoptosis
Bioactivity
NA-17 is a naphthalimide compound with antitumor activity and exhibits lower toxicity to normal cells such as HL-7702 and WI-38. It demonstrates p53-dependent inhibition selectivity in various NSCLC cells, inducing the accumulation of active p53 in the mitochondria and nuclei of these cells. NA-17 causes cell cycle arrest in the G1 phase and promotes apoptosis and cell death.
Smiles
O=C1C2=CC=CC=3C(=CC=C(C(=O)N1CCC4=CC=C5OCOC5=C4)C23)NCCCN(C)C
Molecular Formula
C26H27N3O4
Molecular Weight
445.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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