MEL23
Product Specifications
CAS Number
642072-49-9
Target
Ligand for E3 Ligase
Related Pathways
PROTAC
Bioactivity
MEL23 is an MDM2E3 ligase inhibitor that prevents the E3 ligase activity of the MDM2-MDMX complex. It inhibits the ubiquitination of Mdm2 and p53 in cells, reducing the viability of wild-type p53 cells. Additionally, MEL23 stabilizes MDM2 through a mechanism independent of p53 transcription.
Smiles
O=C1NC(=O)C(C(=O)N1CCCC)C2NCCC=3C=4C=CC=CC4NC32
Molecular Formula
C19H22N4O3
Molecular Weight
354.403
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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