Proteasome-IN-6
Product Specifications
Target
Proteasome|||Parasite
Related Pathways
Proteases/Proteasome|||Microbiology/Virology|||Ubiquitination
Bioactivity
Proteasome-IN-6 (Compound J-80) inhibits the ?5 catalytic subunit of the Trypanosoma brucei 20S proteasome, effectively blocking T. b. brucei, T. b. gambiense, and T. b. rhodesiense with EC50 values of 157 nM, 220 nM, and 156 nM, respectively. Additionally, Proteasome-IN-6 has demonstrated antitrypanosomal activity in a mouse model.
Smiles
CCCCCC(=O)N[C@H](CC(=O)N(CC)CC)C(=O)N[C@@H](CC1=CC=C(C=C1)F)C(=O)N[C@@H](CC2=C(C=C(C=C2)F)F)C(=O)[C@]3(CO3)C
Molecular Formula
C35H45F3N4O6
Molecular Weight
674.75
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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