HL001
Product Specifications
CAS Number
1186371-31-2
Target
LPL Receptor|||Reactive Oxygen Species|||Apoptosis|||MDM-2/p53
Related Pathways
NF-?B|||Apoptosis|||GPCR/G Protein|||Metabolism|||Immunology/Inflammation
Bioactivity
HL001 is an orally active small molecule inhibitor of cyclophilin A (CypA) and a receptor antagonist of lysophosphatidic acid 1 (LPA1) . It induces cell cycle arrest and apoptosis in tumor cells via p53. By downregulating G3BP1, HL001 promotes reactive oxygen species production and DNA damage to stabilize p53. It disrupts the interaction between MDM2 and p53-72R in a CypA-dependent manner. HL001 exhibits antitumor activity and can also be used in research on pulmonary fibrosis.
Smiles
O=C(NC(=O)C=1C(O)=CC=CC1O)NC2C=3C=CC=CC3C=4C=CC=CC42
Molecular Formula
C21H16N2O4
Molecular Weight
360.363
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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