Bfl-1-IN-6
Product Specifications
Target
Bcl-2 Family|||Caspase
Related Pathways
Proteases/Proteasome|||Apoptosis
Bioactivity
Bfl-1-IN-6 (Compound 20) is an orally active inhibitor of Bcl-2-related protein A1 (BFL1) with an IC50 of 19 nM. This compound can stabilize BFL1 protein, activate cleaved caspase 3, and demonstrates antitumor activity in mouse models.
Smiles
C[C@@H](C1=CC=C(C=C1)Cl)N(C2=CC(=C(C=C2)O[C@@H]3CC[C@H](C3)N)F)C(=O)C=C
Molecular Formula
C22H24ClFN2O2
Molecular Weight
402.89
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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