Bfl-1-IN-6

Product Specifications

Target

Bcl-2 Family|||Caspase

Related Pathways

Proteases/Proteasome|||Apoptosis

Bioactivity

Bfl-1-IN-6 (Compound 20) is an orally active inhibitor of Bcl-2-related protein A1 (BFL1) with an IC50 of 19 nM. This compound can stabilize BFL1 protein, activate cleaved caspase 3, and demonstrates antitumor activity in mouse models.

Smiles

C[C@@H](C1=CC=C(C=C1)Cl)N(C2=CC(=C(C=C2)O[C@@H]3CC[C@H](C3)N)F)C(=O)C=C

Molecular Formula

C22H24ClFN2O2

Molecular Weight

402.89

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

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