NLRP3-IN-60
Product Specifications
Target
NOD-like Receptor (NLR), Pyroptosis
Related Pathways
Immunology/Inflammation, Apoptosis
Bioactivity
NLRP3-IN-60 (Compound 39) is an orally bioavailable inhibitor of NLRP3. It effectively suppresses pyroptosis in THP-1 cells with an IC50 of 13 nM and inhibits IL-1β release in human whole blood, exhibiting an IC50 of 225 nM.
Smiles
CC(C)C1=C(C=CC2=C1CC(=O)NS(=O)(=O)C3=CN(C(COC4=NC=CC2=C4)(C)C)N=C3F)F
Molecular Formula
C23H24F2N4O4S
Molecular Weight
490.523
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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