PKMYT1-IN-8
Product Specifications
Target
Ephrin Receptor|||Wee1
Related Pathways
Tyrosine Kinase/Adaptors|||Cell Cycle/Checkpoint
Bioactivity
PKMYT1-IN-8 (Compound 137) is an inhibitor of PKMYT1, with an IC50 value of 9 nM. It also inhibits EPHB3, EPHA1, KIT, EPHB1, EPHA2, EPHA3, and EPHB2, exhibiting IC50 values of 1.79, 3.17, 4.29, 6.32, 6.83, 8.10, and 10.9 ?M, respectively. Additionally, PKMYT1-IN-8 suppresses the proliferation of cancer cells OVCAR3 with a GI50 of 2.02 ?M.
Smiles
CC1=C(C(=C(C=C1)O)C)N2C(=C(C3=C(N=C(N=C32)C)C(F)(F)F)C(=O)N)N
Molecular Formula
C17H16F3N5O2
Molecular Weight
379.336
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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