VU6024578
Product Specifications
Target
GluR
Related Pathways
Neuroscience
Bioactivity
VU6024578 (BI02982816) is an orally bioavailable and selective positive allosteric modulator (PAM) of the metabotropic glutamate receptor mGluR1. It demonstrates activation with EC50 values of 54 nM for human mGluR1 and 46 nM for rat mGluR1. VU6024578 shows antipsychotic activity in rat models of amphetamine-induced hyperactivity and MK-801-induced novel object recognition (NOR) . Additionally, it possesses blood-brain barrier permeability.
Smiles
CN1C(=CC=N1)C2=NN(C(=C2)CNC(=O)C3=C(C=CC(=C3)C4=CC=CO4)Cl)C
Molecular Formula
C20H18ClN5O2
Molecular Weight
395.842
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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