Tubulin/MMP-IN-3
Product Specifications
Target
NF-?B|||Apoptosis|||MMP|||Microtubule Associated
Related Pathways
Apoptosis|||Cytoskeletal Signaling|||NF-?B|||Proteases/Proteasome
Bioactivity
Tubulin/MMP-IN-3 (Compound 15j) is a dual inhibitor of tubulin polymerization and MMP, effectively inhibiting MMP-2 and MMP-9 with IC50 values of 21.13 ?M and 19.24 ?M, respectively. It disrupts the NF-?B signaling pathway, leading to mitochondrial dysfunction and mitochondrial-dependent apoptosis. Tubulin/MMP-IN-3 shows antiproliferative activity in various cancer cells by causing cell cycle arrest at the G2/M phase and demonstrates antitumor effects in mouse models.
Smiles
COC1=CC(C(/C=C/C2=CC=C(OC)C(OC(CC3=CC=C(NC(P(OCC)(OCC)=O)C4=CC=CC([N+]([O-])=O)=C4)C=C3)=O)=C2)=O)=CC(OC)=C1OC
Molecular Formula
C38H41N2O12P
Molecular Weight
748.712
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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