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BMS-986449

Product Specifications

Target

IKZF, Molecular Glues

Related Pathways

PROTAC, Immunology/Inflammation

Purity

0.9887

Bioactivity

BMS-986449 is an IKZF2 (Helios) /IKZF4 (Eos) degrader and CELMoD molecular glue. It redirects the interaction between the E3 ubiquitin ligase Cereblon and Helios/Eos in primary Treg cells, inducing their degradation, and may be utilised for anti-tumour immunotherapy.

Smiles

CC1=C(C)C(N)=NC(C2=C(F)C([C@@H](C)N([C@H]3CCC(NC3=O)=O)C4=O)=C4C=C2)=C1

Molecular Formula

C21H21FN4O3

Molecular Weight

396.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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