BMS-986449
Product Specifications
Target
IKZF|||Molecular Glues
Related Pathways
PROTAC|||Immunology/Inflammation
Purity
0.9887
Bioactivity
BMS-986449 is an IKZF2 (Helios) /IKZF4 (Eos) degrader and CELMoD molecular glue. It redirects the interaction between the E3 ubiquitin ligase Cereblon and Helios/Eos in primary Treg cells, inducing their degradation, and may be utilised for anti-tumour immunotherapy.
Smiles
CC1=C(C)C(N)=NC(C2=C(F)C([C@@H](C)N([C@H]3CCC(NC3=O)=O)C4=O)=C4C=C2)=C1
Molecular Formula
C21H21FN4O3
Molecular Weight
396.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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