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RMC5127

Product Specifications

CAS Number

3056146-38-1

Target

Apoptosis, Kras, Ras, Kras

Related Pathways

GPCR/G Protein, MAPK, Apoptosis

Purity

0.9754

Bioactivity

RMC5127 is an orally available, mutation-selective RAS G12V inhibitor exhibiting central nervous system (CNS) and brain permeability. It suppresses the RAS pathway and induces apoptosis in KRAS G12V mutant cancer cells, demonstrating antitumour activity.

Smiles

C[C@H](OC)C(N=C1)=[C@@]([C@@]2=C(CC(C)(C)COC([C@H]3NN(C([C@@H](NC([C@H]4OC[C@@H]4C)=O)[C@H]5N6CC7(COC7)C6)=O)C8CC3C8)=O)C9=C(C=CC(C%10=CSC5=N%10)=C9)N2CCOC%11CCOCC%11)C=C1N%12CCN(C%13CC%13)CC%12

Molecular Formula

C57H75N9O9S

Molecular Weight

1062.32

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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