CLPP-2068
Product Specifications
Target
ROS, Apoptosis, Protease
Related Pathways
Proteases/Proteasome, Apoptosis, Immunology/Inflammation
Bioactivity
CLPP-2068 has oral activity and is an activator of human casein hydrolase P (HsClpP) (EC50=50.4 nM) . CLPP-2068 exhibits anti proliferative effects (IC50=5.2 nM) in OCI-LY10 cells, and can also reduce mitochondrial membrane potential, increase mitochondrial ROS levels, and induce mitochondrial dysfunction. CLPP-2068 blocks the cell cycle in G1 phase and induces apoptosis in OCI-LY10 cells. CLPP-2068 exhibits anti-tumor activity in a mouse xenograft model.
Smiles
O=C1NC(NCC2=CC=C(Br)C=C2)=NC3=C1CN([C@H](C)C3)CC4=CC(C#N)=CC=C4
Molecular Formula
C23H22BrN5O
Molecular Weight
464.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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