RIPK2/3 IN 29
Product Specifications
Bioactivity
RIPK2/3 inhibitor 29 (compound 29) is a dual inhibitor of RIPK2 (IC50=12 nM) and RIPK3 (IC50=18 nM), which can directly bind to RIPK2 and RIPK3, effectively inhibiting NOD induced cytokine production and cell necrosis. Compound 29 has shown significant therapeutic effects in DSS induced colitis mouse models and has broad potential for dual inhibition of RIPK2/RIPK3 in the treatment of IBD.
Smiles
FC1=CC=CC=C1NC2=NC=NC3=CC(C4=CC=C(N5CCOCC5)N=C4)=CC=C32
Molecular Formula
C23H20FN5O
Molecular Weight
401.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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