Adenine

Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].

Product Specifications

CAS Number

[73-24-5]

UNSPSC

12352005

Hazard Statement

H301, H401

Target

DNA/RNA Synthesis; Endogenous Metabolite

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Adenine.html

Purity

99.99

Solubility

DMSO : ≥ 10 mg/mL|H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=C2N=CNC2=NC=N1

Molecular Formula

C5H5N5

Molecular Weight

135.13

Precautions

H301, H401

References & Citations

[1]ORO J, et al. Synthesis of purines under possible primitive earth conditions. I. Adenine from hydrogen cyanide. Arch Biochem Biophys. 1961 Aug;94:217-27.|[2]Griffiths AJF, et al. An Introduction to Genetic Analysis. 7th edition. New York: W. H. Freeman; 2000. Structure of DNA.|[3]Reader V. The assay of vitamin B (4) . Biochem J. 1930;24 (6) :1827-31.|[4]Yung-Jen Tsai, et al. Pharmacokinetics of Adenosine and Cordycepin, a Bioactive Constituent of Cordyceps sinensis in Rat. J Agric Food Chem 2010 Apr 28;58 (8) :4638-43.|[5]Fatma F Mohamed, et al. Dentoalveolar Alterations in an Adenine‐Induced Chronic Kidney Disease Mouse Model. J Bone Miner Res. 2023 Aug;38 (8) :1192-1207.|[6]Chien-Ning Hsu, et al. Sodium Thiosulfate Improves Hypertension in Rats with Adenine-Induced Chronic Kidney Disease. Antioxidants (Basel) . 2022 Jan 11;11 (1) :147.