BTX6654
Product Specifications
Target
Kras, PROTACs, Ras, ERK
Related Pathways
PROTAC, MAPK
Bioactivity
BTX-6654 is a cereblon-based bifunctional SOS1 PROTAC degrader. This compound exhibits antiproliferative activity against cells with various KRAS mutations by reducing the expression of downstream signaling markers pERK and pS6.
Smiles
FC(F)(F)C1=C(C)C([C@@H](C)NC2=NN=C(C)C3=CC=C(N4CCN(C(C5CCN(C(CCN6CCC(C7=CC(CN(C8CCC(NC8=O)=O)C9=O)=C9C=C7F)CC6)=O)CC5)=O)CC4)C=C32)=CC=C1
Molecular Formula
C50H57F4N9O5
Molecular Weight
940.04
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb501112 100 µL
Phospho-PPM1A (Ser375) Rabbit Polyclonal Antibody (Biotin)
Sign In for Pricing
View Details 
122820-PE 100 µL
ABCG2 (ATP-binding Cassette Sub-family G Member 2, Placenta-specific ATP-binding Cassette Transporter, Breast Cancer Resistance Protein, Mitoxantrone Resistance-associated Protein, CD338 Antigen, CDw338, ABCP, BCRP, BCRP1, MXR) (PE)
Sign In for Pricing
View Details orb1607642 100 µL
Phospho-Smad3 (Ser425) Rabbit Polyclonal Antibody (BF555)
Sign In for Pricing
View Details 
TRV-0031313 96 Tests
Multiplex Assay Kit for Inter Alpha-Globulin Inhibitor H5 (ITIH5), etc. by FLIA (Flow Luminescence Immunoassay)
Sign In for Pricing
View Details 
588933 96 Tests
Alkaline Phosphatase, Tissue-nonspecific (ALPL) BioAssayTM ELISA Kit (Rabbit)
Sign In for Pricing
View Details