What is the catalog number for SOS1-IN-17?

The catalog number for SOS1-IN-17 is T203656.

What sizes are available for SOS1-IN-17?

SOS1-IN-17 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does SOS1-IN-17 come in?

SOS1-IN-17 is available in 2 different pack sizes.

Is SOS1-IN-17 in stock?

SOS1-IN-17 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SOS1-IN-17?

SOS1-IN-17 is manufactured by Molfinity.

What is the estimated delivery time for SOS1-IN-17?

Estimated delivery time for SOS1-IN-17 is approximately 10 business day(s), depending on your location.

SOS1-IN-17

Product Specifications

Target

Ras, Raf

Related Pathways

MAPK, GPCR/G Protein

Bioactivity

SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.