SOS1-IN-17
Product Specifications
Target
Ras|||Raf
Related Pathways
MAPK|||GPCR/G Protein
Bioactivity
SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 ?M. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.
Molecular Formula
C29H34F3N5O2
Molecular Weight
541.61
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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