Perfluorotetradecanoic acid
Product Specifications
CAS Number
376-06-7
Target
PPAR, Apoptosis
Related Pathways
Apoptosis, Metabolism, DNA Damage/DNA Repair
Bioactivity
Perfluorotetradecanoic acid (PFTeDA) is a PPARγ antagonist. It binds to the ligand-binding domain of human PPARγ, with an IC50 of 22.8 μM and a Kd of 157.8 μM. Perfluorotetradecanoic acid inhibits Leydig cell function by inducing oxidative stress and apoptosis (Apoptosis) . Although it stimulates corticosterone biosynthesis, it inhibits aldosterone production.
Smiles
O=C(O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
Molecular Formula
C14HF27O2
Molecular Weight
714.11
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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