Timegadine hydrochloride
Product Specifications
CAS Number
71080-06-3
Target
COX
Related Pathways
Immunology/Inflammation|||Neuroscience
Bioactivity
Timegadine hydrochloride (SR1368 hydrochloride) is the hydrochloride salt form of Timegadine. It is an orally active inhibitor of COX and lipo-oxygenase, effectively suppressing COX in rabbit platelets and rat brain with IC50 values of 5 nM and 20 ?M, respectively, and inhibiting lipo-oxygenase in horse and rabbit platelets with an IC50 of 100 ?M. Timegadine hydrochloride also exhibits anti-arthritis activity.
Smiles
Cl.N=1C=CSC1NC(=NC2=CC(=NC=3C=CC=CC32)C)NC4CCCCC4
Molecular Formula
C20H24ClN5S
Molecular Weight
401.96
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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