HDM-IN-1
Product Specifications
CAS Number
3020690-76-7
Target
Antifungal, Histone Demethylase
Related Pathways
Chromatin/Epigenetic, Microbiology/Virology
Bioactivity
HDM-IN-1 (Compound A4) is an inhibitor of fungal histone demethylase (HDM) that inhibits H3K27me3 in Cryptococcus neoformans and Candida auris, with IC50 values of 134 nM and 12 nM, respectively. It demonstrates inhibitory activity against these fungi by preventing biofilm and capsule formation, with an MIC80 of 0.5-2 μg/mL. Additionally, HDM-IN-1 exhibits antifungal activity in ICR mouse models.
Smiles
N=1C=CC=CC1C(=NNC2=NC=C(OC)C=C2)C3=NC=CC=C3
Molecular Formula
C17H15N5O
Molecular Weight
305.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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