Microtubule inhibitor 12
Product Specifications
Target
Apoptosis, Microtubule Associated
Related Pathways
Apoptosis, Cytoskeletal Signaling
Bioactivity
Microtubule inhibitor 12 (Compound 2k) is a microtubule polymerization inhibitor with an IC50 of 22.23 μM. It causes cell cycle arrest at the G2/M phase in B16-F10 cells, induces apoptosis, and impedes cell migration. This compound inhibits the proliferation of cancer cells B16-F10, A549, HepG2, and MCF-7 with IC50 values of 0.098, 0.135, 0.109, and 0.259 μM, respectively, and demonstrates antitumor activity in mouse models.
Molecular Formula
C22H22N4O3
Molecular Weight
390.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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