5-HT6 inverse agonist 1
Product Specifications
CAS Number
2727088-38-0
Target
5-HT Receptor, mTOR, CDK
Related Pathways
Cell Cycle/Checkpoint, PI3K/Akt/mTOR signaling, Neuroscience, GPCR/G Protein
Bioactivity
5-HT6 inverse agonist 1 (Compound 33) is an antagonist of the 5-HT6 receptor with a Ki of 23 nM and a Kb of 6.62 nM. This compound can inhibit 5-HT6R-mediated Cdk5 and mTOR signaling pathways and reduce tactile allodynia induced by spinal nerve ligation (SNL) in rat models.
Smiles
Cl.O=C(NC1CCNCC1)C=2C=CN(C2C=3C=CC(F)=CC3)S(=O)(=O)C=4C=CC=C(Cl)C4
Molecular Formula
C22H22Cl2FN3O3S
Molecular Weight
498.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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