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CB2 receptor agonist 8

Product Specifications

Target

Caspase|||Cannabinoid Receptor

Related Pathways

Proteases/Proteasome|||GPCR/G Protein|||Apoptosis

Bioactivity

CB2 receptor agonist 8 (Compound 17) is an agonist of the cannabinoid receptor 2 (CB2 receptor) . It shows cytotoxicity in U87, RPMI 8226, HL-60, and L929 cells with IC50 values of 91.03, 16.29, 23.51, and 564.6 ?M, respectively. CB2 receptor agonist 8 activates caspase 3/7, increases the expression of pro-apoptotic genes BAX, BAD, BIM, and the tumor suppressor gene p53, and induces apoptosis in U87 cells. Additionally, it inhibits the migration of U87 cells.

Molecular Formula

C23H26FN3O2

Molecular Weight

395.47

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

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