SBI-810
Product Specifications
CAS Number
1849603-79-7
Target
Neurotensin Receptor
Related Pathways
GPCR/G Protein
Bioactivity
SBI-810 is a functional selective β-arrestin-biased allosteric modulator of the neurotensin receptor 1 (NTSR1) . In the presence of the endogenous ligand neurotensin (NT), SBI-810 regulates NTSR1 signaling through a G protein-specific mechanism. It fully antagonizes NT-induced Gq activation and partially antagonizes NT-induced Gi1 activation, allowing NTSR1 to activate GoA and G12.
Smiles
OCCN(C=1C=CC=2N=C(N=C(C2C1)N3CCC(C=4C=CC=CC4OC)CC3)C5(C)CC5)C
Molecular Formula
C27H34N4O2
Molecular Weight
446.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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