Tyk2-IN-22
Product Specifications
CAS Number
933667-23-3
Target
JAK
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, Stem Cells, JAK/STAT signaling, Chromatin/Epigenetic
Bioactivity
Tyk2-IN-22 (Compound A8) is a selective inhibitor of tyrosine kinase 2 (Tyk2), effectively inhibiting Tyk2, JAK1, and JAK3 with IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM, respectively. Additionally, Tyk2-IN-22 suppresses downstream STAT5 phosphorylation.
Smiles
O=C1C=C(N=C2NC(=NN12)C=3C=CC(Cl)=CC3)CN4CCOCC4
Molecular Formula
C16H16ClN5O2
Molecular Weight
345.78
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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