FKK6
Product Specifications
CAS Number
2238839-34-2
Target
Interleukin, NF-κB
Related Pathways
NF-κB, Immunology/Inflammation
Bioactivity
FKK6 is a selective agonist of the pregnane X receptor (PXR) with an EC50 of 1.2 μM. It demonstrates strong affinity for plasma proteins and exhibits favorable metabolic characteristics in human microsomes. FKK6 inhibits the PXR-related NF-κB signaling pathway, reducing the expression of inflammatory factors and showing anti-inflammatory activity in a mouse model of DSS-induced colitis.
Smiles
O=S(=O)(C=1C=CC=CC1)N2C=3C=CC=CC3C=C2C(O)(C=4C=CN=CC4)CC#C
Molecular Formula
C23H18N2O3S
Molecular Weight
402.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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