VEGFR-2/AKT-IN-2
Product Specifications
Target
Apoptosis, Akt, Bcl-2 Family, Caspase, VEGFR
Related Pathways
Angiogenesis, Proteases/Proteasome, Apoptosis, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling
Bioactivity
VEGFR-2/AKT-IN-2 (Compound 5) is an inhibitor of VEGFR-2/AKT, with an IC50 of 0.061 μM for VEGFR in human liver cancer cells. It reduces total and phosphorylated AKT in cells, increases BAX and caspase-3 levels, and decreases Bcl-2, thereby inducing apoptosis. Additionally, VEGFR-2/AKT-IN-2 halts the cell cycle at the S phase and inhibits the growth of human liver cancer cells.
Molecular Formula
C25H16FN5S
Molecular Weight
437.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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