STAT3-IN-38
Product Specifications
CAS Number
3033049-16-7
Target
Apoptosis, STAT, Survivin
Related Pathways
Stem Cells, JAK/STAT signaling, Apoptosis
Bioactivity
STAT3-IN-38 (Compound 4m) is a STAT3 inhibitor with a dissociation constant (K_D) of 45.33 μM for rhSTAT3, and is a derivative of Celastrol. It binds to the SH2 domain of the STAT3 protein, inhibiting phosphorylation at the pTyr705 site and suppressing downstream gene expression of Survivin and Mcl-1. STAT3-IN-38 can arrest the cell cycle and induce apoptosis in colorectal cancer cells.
Smiles
C[C@@]12[C@](C)([C@]3([C@@](C)(CC1)CC[C@](C(NCCC4=CC=CS4)=O)(C)C3)[H])CC[C@]5(C)C2=CC=C6C5=CC(=O)C(O)=C6C
Molecular Formula
C35H45NO3S
Molecular Weight
559.8
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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