BCL-XL-IN-3
Product Specifications
CAS Number
1949840-87-2
Target
Bcl-2 Family
Related Pathways
Apoptosis
Bioactivity
BCL-XL-IN-3 (Compound 11) is an inhibitor of BCL-XL, with a Ki of less than 0.01 nM. It suppresses cell viability in both normal Molt-4 cells and digitonin-permeabilized Molt-4 cells, with EC50 values of 77.8 nM and 0.07 nM, respectively. BCL-XL-IN-3 can be utilized as an ADC toxin for synthesizing Clezutoclax.
Smiles
C(C12CC3(OCCNCC[C@@H](CO)O)CC(C)(C1)CC(C)(C2)C3)N4C(C)=C(C=N4)C5=C(C(O)=O)N=C(C=C5)N6CC7=C(C(NC8=NC=9C(S8)=CC=CC9)=O)C=CC=C7CC6
Molecular Formula
C46H55N7O6S
Molecular Weight
834.04
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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