MI-1063
Product Specifications
CAS Number
1410737-39-1
Target
Ligands for Target Protein for PROTAC|||MDM-2/p53
Related Pathways
PROTAC|||Apoptosis
Bioactivity
MI-1063 is a DMD-2 inhibitor that prevents the MDM2-p53 interaction and activates p53's tumor-suppressing abilities. It inhibits the growth of cancer cells RS4-11 and MV4-11, with IC50 values of 179 nM and 93 nM, respectively. MI-1063 serves as a target protein ligand for the synthesis of the PROTAC degrader [MD-265].
Smiles
O=C1[C@@]2(C3(N[C@@H](C(N[C@H]4CC[C@H](C(O)=O)CC4)=O)[C@@H]2C5=C(F)C(Cl)=CC=C5)CCCCC3)C=6C(N1)=CC(Cl)=CC6
Molecular Formula
C30H32Cl2FN3O4
Molecular Weight
588.5
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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