SD-436
Product Specifications
CAS Number
2497585-50-7
Target
STAT|||PROTACs
Related Pathways
JAK/STAT signaling|||Stem Cells|||PROTAC
Purity
0.9934
Bioactivity
SD-436 is a selective and highly efficient STAT3 PROTAC degrader (DC50 = 0.5 ?M), with an IC50 of 19 nM for STAT3, significantly higher than for STAT1/4/5/6. SD-436 depletes STAT3 and induces tumour regression in mouse leukaemia and lymphoma xenograft models.
Smiles
C(#CCCC1CCN(C([C@H](CC2=CC(F)=C(F)C=C2)NC([C@@H](NC(=O)[C@H]3N4[C@](CC3)(CCN(C(OC)=O)C[C@H](NC(=O)C5=CC=6C(S5)=CC=C(C(P(=O)(O)O)(F)F)C6)C4=O)[H])CCC(N)=O)=O)=O)CC1)C7=C8C(C(=O)N(C8)C9C(=O)NC(=O)CC9)=CC=C7
Molecular Formula
C58H62F4N9O14PS
Molecular Weight
1248.2
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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