GSK163929
Product Specifications
CAS Number
716354-04-0
Target
HIV Protease|||CCR
Related Pathways
Microbiology/Virology|||GPCR/G Protein|||Immunology/Inflammation|||Proteases/Proteasome
Bioactivity
GSK163929 (compound 122) is an orally active CCR5 antagonist with anti-HIV properties and demonstrates low inhibitory potency against hEGR. Administered at a dosage of 2000 mg/kg/day (i.v., 7 d), it shows no adverse effects in rats, and at 250 mg/kg/day (i.v., 7 d), it is similarly non-toxic in dogs.
Smiles
C(CN1[C@@]2(C[C@H](C[C@]1(CC2)[H])N3C=4C(N=C3C)=CC=CC4)[H])C5(CCN(C(=O)C6=CC(S(NC)(=O)=O)=C(F)C=C6Cl)CC5)C7=CC(F)=CC=C7
Molecular Formula
C36H40ClF2N5O3S
Molecular Weight
696.25
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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