MC3343
Product Specifications
CAS Number
1535187-91-7
Target
DNA Methyltransferase
Related Pathways
Chromatin/Epigenetic
Purity
0.9973
Bioactivity
MC3343, a DNMT inhibitor with IC50 values of 5.7 μM for DNMT1 and 1.7 μM for DNMT3a, affects tumor proliferation by blocking osteosarcoma cells in the G1 or G2/M phase and induces osteogenic differentiation by specifically re-expressing genes that regulate this physiological process, and is able to show synergistic effects in combination with adriamycin and cisplatin (CDDP) .
Smiles
O=C(NC=1C=CC=C(C1)NC2=NC(=NC(=C2)C)N)C=3C=CC=C(C3)NC=4C=CN=C5C=CC=CC54
Molecular Formula
C27H23N7O
Molecular Weight
461.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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