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COX-2/15-LOX-IN-6

Product Specifications

Target

Lipoxygenase, COX

Related Pathways

Immunology/Inflammation, Metabolism, Neuroscience

Bioactivity

COX-2/15-LOX-IN-6 (Compound 5l) is a dual inhibitor of COX-2 and 15-LOX with IC50 values of 0.201 μM and 11.723 μM, respectively. In serum, it suppresses the expression of PGE, TNF-α, IL-6, and iNOS, and demonstrates anti-inflammatory activity in a carrageenan-induced rat edema model.

Molecular Formula

C31H28N4O4S

Molecular Weight

552.64

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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