PROTAC ERα Degrader-10
Product Specifications
CAS Number
2421260-43-5
Target
Estrogen Receptor/ERR, PROTACs
Related Pathways
Endocrinology/Hormones, PROTAC
Bioactivity
PROTACERα Degrader-10 (Compound 160a) is an orally bioavailable ERα degrader with a DC50 of 0.37-1.1 nM in MCF7, T47D, and CAMA-1 cells. It demonstrates antitumor activity in mouse models.
Smiles
C(=C(/CC)\C1=CC=CC=C1)(\C2=CC=C(C=C2)N3CCC(CN4CCN(CC4)C=5C=C6C(=CC5)C(=O)N(C6)[C@@H]7C(=O)NC(=O)CC7)CC3)/C8=CC=C(O)C=C8
Molecular Formula
C45H49N5O4
Molecular Weight
723.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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