PPL agonist-1
Product Specifications
CAS Number
3040997-52-9
Target
Microtubule Associated, Tyrosinase
Related Pathways
Proteases/Proteasome, Cytoskeletal Signaling
Bioactivity
PPL agonist-1 (Compound I-3) is a highly selective agonist of Periplakin (PPL) that raises cAMP levels by modulating PPL, enhancing MITF expression, and consequently promoting melanin synthesis. Additionally, it stimulates melanin production by regulating tryptophan metabolism. Compared to Ruxolitinib, PPL agonist-1 demonstrates superior effectiveness and holds potential for vitiligo research.
Smiles
CC=1C=C(C2=CC=C([C@@H](NC=3N=C(NS(=O)(=O)C4=CC(N(=O)=O)=CC=C4)C=CN3)C)C=C2)C=CC1F
Molecular Formula
C25H22FN5O4S
Molecular Weight
507.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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