Nrf2 activator 18
Product Specifications
Target
Others|||Nrf2
Related Pathways
Others|||Immunology/Inflammation
Bioactivity
Nrf2 activator 18 (Compound 11a) is an orally active activator of the Keap1/Nrf2/HO-1 signaling pathway, promoting Nrf2 nuclear translocation and enhancing antioxidant effects. It inhibits IL-6 release with an IC50 of 4.816 ?M. In a mouse model of PM2.5-induced lung injury, Nrf2 activator 18 demonstrates anti-inflammatory activity.
Molecular Formula
C23H24FN3O
Molecular Weight
377.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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