YT 6-2 analog-1
Product Specifications
CAS Number
2409960-12-7
Target
AUTACs
Related Pathways
PROTAC
Bioactivity
YT 6-2 analog-1 (compound 2-3) serves as an autophagy-targeting ligand (ATL) aimed at p62/SQSTM1, useful in synthesizing the AUTOTAC degrader ATC-324 for the Androgen Receptor (AR) . ATC-324 promotes the formation of AR/p62 complexes, leading to the autophagic-lysosomal degradation of AR. It effectively reduces nuclear AR levels, downregulates the expression of AR and AR-v7 target genes, and can degrade common AR mutants found in prostate cancer (PCa) .
Smiles
O(CC1=CC=C(F)C=C1)C2=C(OCC3=CC=C(F)C=C3)C=CC(OC[C@H]4CO4)=C2
Molecular Formula
C23H20F2O4
Molecular Weight
398.4
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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