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PDE1-IN-9

Product Specifications

CAS Number

2982945-41-3

Target

NO Synthase|||PDE

Related Pathways

Immunology/Inflammation|||Metabolism

Bioactivity

PDE1-IN-9 (Compound 7a) is a selective inhibitor of phosphodiesterase 1 (PDE1), targeting PDE1C with an IC50 value of 11 nM. It effectively reduces the mRNA expression of IL-1?, IL-6, TNF-?, and iNOS, while also inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS) . Additionally, PDE1-IN-9 demonstrates good metabolic stability in rat liver microsomes.

Smiles

N#CC=1C(=O)N(C=2C=C(C=CC2C1C3CCCC3)NCC4CCOCC4)CC=5C=CC=CC5

Molecular Formula

C28H31N3O2

Molecular Weight

441.57

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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