Clozapine dihydrochloride
Product Specifications
CAS Number
2711603-38-0
Target
Dopamine Receptor, 5-HT Receptor, AChR, Adrenergic Receptor
Related Pathways
GPCR/G Protein, Neuroscience
Bioactivity
Clozapine (HF 1854) dihydrochloride is utilized for researching psychiatric disorders. This compound exhibits high affinity for numerous neuroreceptors and acts as an effective antagonist of dopamine receptors, with a Ki value of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor, with Ki values of 9.5 nM and 4 nM, respectively. Additionally, Clozapine is a selective agonist of the muscarinic M4 receptor (EC50 = 11 nM) .
Smiles
ClC1=CC=C2NC3=C(C(N4CCN(CC4)C)=NC2=C1)C=CC=C3.Cl.Cl
Molecular Formula
C18H21Cl3N4
Molecular Weight
399.75
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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